Natural product development and testing
Discovery of new anti-inflammatory pharmaceuticals, use of natural products to control inflammation, discovery of novel mechanisms to control inflammation
Relevant Research Projects
Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-kB-dependent transcription of TNF-a and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA. J. Inflamm., 2010.
Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by
the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis). Int. Immunopharmacol, 2011.
Ethanolic Echinacea purpurea extracts contain a mixture of cytokine-suppressive and cytokine-inducing compounds, including some that originate from endophytic bacteria. PLOS ONE, 2015.
1,200-square-foot lab equipped to study immunity and inflammation
Ph.D., Biological Sciences, Florida State University, 1984
Member, USDA animal health study section, 2011-2013
Member, Porcine Reproductive and Respiratory Syndrome Virus Regional Committee, USDA, 1999-2005
Associate editor, Journal of Immunology, 2001-2004. Various other editorial/review positions
Leader, NCSU Graduate Concentration in Immunology